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Tumor suppressor candidate protein in PTEN turnover identified.
2004 JUL 7 - (NewsRx.com & NewsRx.net) -- Scientists have identified a tumor suppressor candidate protein in phosphatase and tensin homologue deleted on chromosome 10 (PTEN) turnover.
According to published research from Japan, "The turnout suppressor PTEN (phosphatase and tensin homologue deleted on chromosome 10) plays essential roles in regulating signaling pathways involved in cell growth and apoptosis, and is inactivated in a wide variety of tumors. The role of PTEN as a turnout suppressor has been firmly established; however, the mechanisms by which its function and activity are regulated remains elusive."
"Here, we summarize recent progress in research directed towards trying to understand the molecular basis of regulatory mechanisms for PTEN," said Tomohiko Maehama and colleagues at the Tokyo Metropolitan Institute of Medical Science. "We also describe our novel finding that a turnout suppressor candidate protein binds to extreme C-terminal region of PTEN ...
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Source: HighBeam Research, Tumor suppressor candidate protein in PTEN turnover identified.