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Toll-like receptor signals needed to reverse regulatory CD8 tolerance.
2004 JUL 7 - (NewsRx.com & NewsRx.net) -- Persistent Toll-like receptor signals are required for reversal of regulatory T cell-mediated CD8 tolerance.
According to a study from the United States, "One chief barrier to cancer immunotherapy is tumor-specific T cell tolerance. Here we compared the ability of hemagglutinin (HA)-encoding recombinant viruses versus 'HA-loaded' dendritic cells to reverse HA-specific CD8 tolerance and to protect mice from tumor challenge. Both vaccines were comparable in activating naive HA-specific CD8+ T cells."
"However, in circumstances of established tolerance, viral vaccines could break CD8 tolerance in the presence of CD4+CD25+ regulatory T cells, whereas dendritic cell-based vaccines achieved this only after removal of regulatory T cells or the co-administration of a Toll-like receptor (TLR) ligand or irrelevant virus," said Yiping Yang and collaborators at Duke University and Johns Hopkins University. "These results demonstrate that virus provides TLR signals required for bypassing regulatory T ...
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Source: HighBeam Research, Toll-like receptor signals needed to reverse regulatory CD8 tolerance.