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UVB-irradiated dendritic cells fail to tolerize murine CD8+ T cells.
2004 JUL 7 - (NewsRx.com & NewsRx.net) -- UVB-irradiated dendritic cells fail to tolerize murine CD8+ naive or effector T cells.
"UVB radiation has been shown to induce T cell tolerance most likely via modulation of the function of antigen-presenting cells like dendritic cells (DC), which are therefore of interest for vaccination therapy. Since little is known about the effects of UVB-irradiated dendritic cells (UVB-DC) on CD8+ T cells, which are the dominant effectors in various allergic and autoimmune diseases, we have investigated the potential of low-dose UVB (100200 J/m[superscript]2) irradiated bone marrow-derived dendritic cells to induce tolerance in murine CD8+ T cells specific for the contact allergen trinitrophenyl (TNP) or for a viral peptide," investigators in Germany report.
"In contrast to the previously reported successful tolerization of primed CD4+ Th1 cells, neither naive CD8+ T cells nor CD8+ Tc1 effector cells or established CD8+ T cell clones could be tolerized by TNP-modified or peptide-pulsed UVB-DC in vitro or in vivo," said Jan C. Dudda and colleagues at the University of Freiburg. "We observed, however, a reduced capacity of UVB-DC ...
- UVB-irradiated dendritic cells fail to tolerize murine CD8+ T cells.
- Newspaper article from: Health & Medicine Week July 5, 2004 700+ words
...NewsRx.net) -- UVB-irradiated dendritic cells fail to tolerize murine...the effects of UVB-irradiated dendritic cells (UVB-DC) on CD8...Investigative Dermatology (UVB-irradiated dendritic cells fail to tolerize murine...
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