Molecular analysis of adenovirus isolates from young adults reported.

2004 JUL 7 - (NewsRx.com & NewsRx.net) -- Researchers have performed a molecular analysis of adenovirus isolates from vaccinated and unvaccinated young adults.

"Infections of adenovirus type 4 (Ad4) and Ad7 were discovered among previously vaccinated individuals through febrile respiratory illness surveillance at military recruit camps. Genetic analysis was performed on these isolates and a sample of adenovirus isolates from unvaccinated patients. Antigenic regions of the adenovirus hexon gene from 21 vaccinated and 31 unvaccinated patients were sequenced and compared to homologous regions of Ad4 and Ad7 vaccine strains and of other representative hexon sequences archived in GenBank," scientists in the United States report.

"The phylogenetic distribution of sequences from vaccinated individuals closely resembled those from unvaccinated individuals," said Daniel A. Blasiole and collaborators at the Naval Health Research Center and University of California in San Diego. "The most common Ad7 strain was the Ad7d2 hexon genotype, and the most common Ad4 strain was a genotype nearly identical to the recently discovered Z-G 95-873 Ad4 variant. Near exclusive isolation of Ad4 since 1999 indicates that the Ad4 variant is currently responsible for the vast majority of adenovirus ...