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Flagellin fusion proteins induce specific immune responses.
2004 JUL 7 - (NewsRx.com & NewsRx.net) -- Flagellin fusion proteins as adjuvants or vaccines induce specific immune responses.
"Vaccination is the most efficient prophylaxis against a variety of infectious diseases. New vaccination strategies rely on the incorporation of effective adjuvants, which stimulate the innate immune response and, in turn, activate the adaptive immune response. It is well established that flagellin induces inflammatory responses through the activation of antigen-presenting cells (APCs)," investigators in the United States report.
"In order to evaluate whether flagellin can serve as a carrier for the development of adjuvants or vaccines, we prepared a flagellin-enhanced green fluorescent protein (EGFP) fusion protein," said Camilo Cuadros and colleagues at the Sidney Kimmel Cancer Center. "Our results demonstrate that a flagellin-EGFP fusion protein is capable of stimulating APCs, resulting in the maturation of these cells and secretion of proinflammatory cytokines. Furthermore, APCs pulsed with the flagellin-EGFP fusion protein effectively process and present EGFP antigens."
"More importantly, animals immunized with the flagellin-EGFP fusion protein developed specific anti-EGFP ...
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- Newspaper article from: Proteomics Weekly October 5, 2009 700+ words
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Source: HighBeam Research, Flagellin fusion proteins induce specific immune responses.