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T cells primed by DCs pulsed with hepatoma acid-eluted substances.
2004 JUL 7 - (NewsRx.com & NewsRx.net) -- Natural killer T cells can be primed in vivo by dendritic cells (DCs) pulsed with hepatoma-derived acid-eluted substances.
"Many murine tumor cells express not only individual haplotype-matched class I MHC molecules, but also species-specific CD1d molecules. The former class I MHC molecules generally present internally synthesized tumor-derived peptide antigens to highly specific CD8+ cytotoxic T lymphocytes (CTLs) in acquired immunity. In contrast, the latter CD1d molecules may present tumor-associated glycolipid antigens to broadly cross-reactive natural killer T (NKT) cells, which might correlate with controlling tumor metastasis," researchers in Japan report.
"Here, we showed that murine hepatoma cell line Hepal-6-derived acid-eluted substances might contain both D[superscript]b class I MHC-restricted antigens and CD1d-restriced substances, which could sensitize not only syngeneic bone marrow-derived DCs (BM-DCs), but also allogeneic BM-DCs expressing haplotype-mismatched class I MHC and species-specific CD1d molecules," stated Ritsuko Ishii and colleagues at Nippon Medical School. "To our surprise, intravenous (i.v.) immunization of C57BL/6 mice with the former syngeneic BM-DCs carrying acid-eluted materials primed both ...
- T cells primed by DCs pulsed with hepatoma acid-eluted substances.
- Newspaper article from: Drug Week July 9, 2004 700+ words
...pulsed with hepatoma-derived acid-eluted substances. "Many murine tumor...cell line Hepal-6-derived acid-eluted substances might contain both...allogeneic DCs and tumor-derived acid-eluted substances." Ishii and associates...
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...year's top new skin care launches represented new strides for anti-aging products. With the introduction of sugar-derived acid alternatives and vitamins used in their purest forms, skin care manufacturers delivered what consumers wanted: immediate...