AccessMyLibrary provides FREE access to over 30 million articles from top publications available through your library.
Create a link to this page
Copy and paste this link tag into your Web page or blog:
Recombinant IGF-1 gene therapy may improve nerve structure, function recovery.
2004 JUL 1 - (NewsRx.com & NewsRx.net) -- Recombinant human insulin-like growth factor-1 gene therapy has the potential to improve recovery of pudendal nerve structure and function, a study in rats suggests.
"Injured nerves and their motor units may undergo enhanced recovery when exposed to recombinant human insulin-like growth factor-1 (rhIGF-1)," said scientists writing in the International Urogynecology Journal.
In their study, "[t]he external anal sphincter muscle in the female rat was denervated to model incontinence. The treatment-group muscle was injected with rhIGF-1 plasmid, whereas in the control group the plasmid lacked the cDNA insert and the normal group received neither surgery nor treatment."
J.M. Kerns and colleagues at Rush Presbyterian-St. Luke's Medical Center reported that "[e]lectromyography data at 56 days post-surgery indicated more re-innervation without fibrillation potentials in the treatment group (2 of 6) than in the control group (0 of 6).
"The histology of the regenerated axons in the pudendal nerve distal to the crush site also suggested an improved recovery in the treatment group. The number of motor neurons retrogradely labeled with horseradish ...
- Loss of Elastic Fibers Leads to Incontinence and Other Female Pelvic Floor...
- News wire article from: AScribe Health News Service January 24, 2006 700+ words
...reproductive organs and pelvic floor are rich in elastic...complex and severe pelvic floor disorders," Li said...etiology of common pelvic floor disorders among older...LOXL1 by protein or gene therapy could potentially be...
- Pelvic floor muscle training for prevention of female urinary incontinence.
- Magazine article from: New Zealand Journal of Physiotherapy Hay-Smith, Jean July 1, 2003 700+ words
...Morkved S, Bo K, Schei B, Salvesen KA. Pelvic floor muscle training during pregnancy to...treatment arms, (a) intensive antenatal pelvic floor muscle training, and (b) standard...women received individual instruction in pelvic floor anatomy, and had a correct pelvic ...
- Care of the pelvic floor during pregnancy, birth, and postpartum.(Pregnancy and...
- Newspaper article from: Special Delivery Silva, Alicia September 22, 2005 700+ words
...conveyed to pregnant women, often underemphasized is how to properly care for the pelvic floor during the childbearing year and beyond. The Pelvic Floor The pelvic floor is a supporting structure for the pelvic and abdominal organs, including the...
- Combo approach eases pelvic floor dysfunction.(Geriatric Medicine)
- Magazine article from: Family Practice News Splete, Heidi March 1, 2005 700+ words
...didn't have a complete perspective on pelvic floor dysfunction. Fellows in colorectal...multidisciplinary approach to women's pelvic floor disorders is important, because multiple pelvic floor defects often exist in the absence of...
- Combined approach helps ease pelvic floor dysfunction.(Gynecology)
- Magazine article from: OB GYN News Splete, Heidi March 1, 2005 700+ words
...didn't have a complete perspective on pelvic floor dysfunction. Fellows in colorectal...multidisciplinary approach to women's pelvic floor disorders is important, because multiple pelvic floor defects often exist in the absence of...
- Pelvic Floor Fitness: Better Sex and Bladder Control are Just a Few Squeezes...
- Press release article from: PR Newswire July 27, 2006 700+ words
...role in their quality of life. The pelvic floor, a thin, interlocking hammock of muscle...accidentalsisterhood.com/. "A weak pelvic floor can lead to a variety of life-restricting...that contribute to the weakening of pelvic floor muscles. Pregnancy, childbirth and...
- Pelvic-floor muscle function in women with pelvic organ prolapse.
- Magazine article from: Physical Therapy Borello-France, Diane F. Handa, Victoria L. Brown, Morton B. Goode, Patricia Kreder, Karl Scheufele, Laura L. Weber, Anne M. April 1, 2007 700+ words
...organs depends on the integrity of the pelvic-floor muscles, the supportive connective...and normal innervation. (7) The pelvic-floor muscles include the pubococcygeus...leading to prolapse. (7) Loss of pelvic-floor muscle support is only one of the many...
- Pelvic-floor reeducation with interferential currents and exercise in the...
- Magazine article from: Physical Therapy Dumoulin, Chantale Seaborne, Derek E. Quirion-DeGirardi, Cecile Sullivan, S. John December 1, 1995 700+ words
...Guiron-DeGirardi C, Sullivan SJ. Pelvic-floor rehabilitation, part 2: pelvic-floor reeducation with interferential currents...Neuromuscular electrical stimulation, Pelvic floor, Pelvic-floor exercises, Perineometer...
Source: HighBeam Research, Recombinant IGF-1 gene therapy may improve nerve structure, function...