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Maternal IgG appears phenotypically in offspring as non-genetic inheritance.
2004 JUL 1 - (NewsRx.com & NewsRx.net) -- Maternal IgG appears phenotypically in offspring as anon-genetic inheritance.
"Maternal antibodies provide offspring with passive immunity and exert various active immunostimulatory functions, such as (i) antimicrobial protection through non-antigen-reactive antibodies, namely anti-idiotypes, (ii) allergen-specific suppression of IgE responsiveness and (iii) under pathological conditions, transfer of autoimmune diseases," researchers in Germany report.
"As products of mainly T cell-dependent immune responses with long-lived antigen-independent plasma cells, maternal IgG molecules have undergone immune maturation by somatic hypermutations and are therefore acquired immunological phenotypes representing the collective immunological experience of the mother," wrote H. Lemke and colleagues.
Lemke continued, "The inductive function of maternal IgG, although limited to a neonatal imprinting period, exerts a life-long determinative influence which can dominate ...
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...is present in both the blood and tissues, and is the only antibody to cross the placenta from the mother to the fetus. Maternal IgG protects the newborn for the first months of life, until the infant's immune system produces its own antibodies. IgA...
Source: HighBeam Research, Maternal IgG appears phenotypically in offspring as non-genetic...