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Maternal FA ingestion may effect immunological tolerance in offspring.
2004 JUL 1 - (NewsRx.com & NewsRx.net) -- Maternal essential fatty acid ingestion may effect immunological tolerance in offspring.
According to published research from Sweden, "The present study examines whether dietary essential fatty acid (EFA) intake influences the induction of oral tolerance to ovalbumin (OA) in neonatal and adult rats."
"During late gestation and throughout lactation Sprague-Dawley rats were fed a diet supplemented (S) with EFA (7% soybean oil), or a diet deficient (D) in EFA (7% hydrogenated lard). The rat offspring were subsequently exposed to OA either via the milk at 10-16 days (neonatal rats), or as adults via the drinking water at 7-9 wk of age.
"Oral administration of OA to the adult rats lead to suppression of the delayed-type hypersensitivity (DTH) reactivity and IgG antibody response against OA," reported M. Korotkova and colleagues, "which was not influenced by their diets. In the offspring of the dams fed the D diet antigen exposure via the milk resulted in suppression of the serum antibody levels and DTH reaction against OA indicating induction of oral tolerance."
Korotkova continued, "Higher transforming growth factor beta (TGF-beta) mRNA levels in the draining lymph nodes suggested this to be mediated by ...
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Source: HighBeam Research, Maternal FA ingestion may effect immunological tolerance in offspring.