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Study finds tibolone associated with time-dependent changes in lipid profiles.

Women's Health Weekly

| July 01, 2004 | COPYRIGHT 2004 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

2004 JUL 1 - (NewsRx.com & NewsRx.net) -- Data from a study in France showed time-dependent changes in lipid profiles of women taking tibolone.

The finding differs from results reported in the Heart and Estrogen/Progestin Replacement Study.

T. Alper and colleagues in Turkey compared "the effects of oral conjugated estrogen (CEE) alone, CEE plus medroxyprogesterone acetate (MPA), and tibolone on lipid profiles, and [investigated] whether these effects change in time."

To do this, they looked at plasma lipid levels in the women on CEE (n=49), CEE + MPA (n=50), and tibolone (n=51). "Mean percent changes at certain intervals were compared with their previous intervals for each therapy. Paired t-test was used for statistical analysis," the researchers said.

They found that "CEE alone had raised high-density lipoprotein (HDL) and triglyceride levels and lowered total cholesterol and low-density lipoprotein (LDL) levels at the end of the 2-year study period.

"Addition of MPA to the CEE regimen weakened the effect on HDL and triglyceride, augmented the decrease in total cholesterol, and did not affect LDL," they reported.

"The tibolone group revealed similar but more prominent effects in total cholesterol and LDL levels," according to the team. "HDL and ...

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