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Long-term tibolone therapy appears to benefit lipid profile.
2004 JUL 1 - (NewsRx.com & NewsRx.net) -- Long-term treatment with tibolone was well-tolerated in postmenopausal women with mild hypercholesterolemia and appeared to improve their lipid profiles.
Researchers in Greece studied "the effects of 5-year therapy with tibolone on the lipid profile in postmenopausal women with mild hypercholesterolemia (total cholesterol, 241 [+ or -] 7 mg/dl; LDL cholesterol, 153 [+ or -] 9 mg/dl).
"Eighty-two patients were divided into two groups. Group A (53 women) received 2.5 mg of tibolone per day. Group B (29 women) received no tibolone," according to the study report.
"Total, low- and high-density lipoprotein cholesterol and lipoprotein(a) were found to be decreased in the ribolone group, by 17.7%, 32%, 15.5% and 12%, respectively (p
In the treatment group, "menopausal symptoms disappeared ... within the first 5 months, whereas they deteriorated in the control group during the first 2 years," reported the researchers.
"Although a few unwanted side effects on hormone-dependent tissues were observed (including vaginal spotting in 11.3% and febrile hemorrhagic cystic mastopathy in 3.8%) long-term therapy with tibolone seemed to be ...
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- Long-term tibolone therapy appears to benefit lipid profile.
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Source: HighBeam Research, Long-term tibolone therapy appears to benefit lipid profile.