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Case report shows adenocarcinoma producing only free beta subunit of hCG.

Women's Health Weekly

| July 01, 2004 | COPYRIGHT 2004 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

2004 JUL 1 - (NewsRx.com & NewsRx.net) -- Researchers from the University of North Carolina, Chapel Hill, have reported a case of endometrial adenocarcinoma producing only the free beta subunit of human chorionic gonadotropin (hCG).

The case involved a 24-year-old woman with a histologic grade II endometrial adenocarcinoma without trophoblastic differentiation with an elevated serum concentration of hCG. She wasn't pregnant.

"Serum and urine specimens were used to study the hCG immunoreactivity. Qualitative tests performed on serum and urine using 5 different assays produced conflicting results," the authors reported.

"The hCG concentration in serum and urine was quantified using assays designed to detect different molecular forms of the molecule; analysis revealed that serum hCG immunoreactivity was due entirely to the presence of the free beta subunit," said D.G. Grenache and colleagues.

"Immunohistochemical analysis performed on tissue samples showed strong cytoplasmic staining for hCG," they said.

"While hCG is a well recognized tumor marker in gynecologic malignant neoplasms, ...

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