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Synthetic hormone in contraceptives, HRT causes negative effects in monkeys.
2004 JUL 1 - (NewsRx.com & NewsRx.net) -- Medroxyprogesterone acetate (MPA), a synthetic form of the naturally-occurring steroid hormone progesterone widely used in contraceptives and hormone replacement therapy (HRT), increases aggression and anxiety and reduces sexual activity in female monkeys, study results show.
The investigators, from the Yerkes National Primate Research Center of Emory University and the Center for Behavioral Neuroscience (CBN) in Atlanta, Georiga, say the findings, published in the June 2004 Journal of Clinical Endocrinology and Metabolism, may explain anecdotal reports of mood changes, depression, and loss of libido in some women who use MPA for contraception and HRT.
In the counter balanced-designed study, Yerkes and CBN postdoctoral fellow Karen Pazol, PhD, compared aggression, anxiety, and sexual behavior in six female pigtail macaques that received 1 week each of three different treatments: estrogen only, estrogen plus natural progesterone, and estrogen plus MPA.
Monkeys displayed significantly more aggressive and anxious behaviors when they received the estrogen/MPA combination as compared to when they received the estrogen only or the estrogen/progesterone combination. Pazol also noted a marked reduction in sexual activity during the estrogen/MPA treatment period.
"Our findings suggest MPA may ...
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Source: HighBeam Research, Synthetic hormone in contraceptives, HRT causes negative effects in...