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Pro-inflammatory cytokines not risk factors in older Korean women.
2004 JUL 1 - (NewsRx.com & NewsRx.net) -- Researchers explored the possibility that pro-inflammatory cytokine-induced systemic inflammation might be influential prior to the onset of type 2 diabetes, but they failed to make the connection.
"This study was performed to compare concentrations of pro-inflammatory cytokines, such as interleukin 6 (IL-6), tumor necrosis factor alpha (TNF-alpha), as well as acute-phase proteins, such as C-reactive protein (CRP), between subjects with normal glucose tolerance (NGT) and impaired glucose tolerance (IGT)," reported K.M. Choi and colleagues at Korea University, Guro Hospital.
They wanted "to verify whether the pro-inflammatory cytokine-induced acute-phase response is a pathogenic mechanism in type 2 diabetes in elderly Korean women."
Choi and colleagues wrote: "Our study confirms that increased acute-phase reaction is associated with impaired glucose tolerance and the metabolic syndrome in elderly Korean women. However, the hypothesis that pro-inflammatory cytokine-induced systemic inflammation is an early metabolic defect prior to onset of type 2 diabetes, is not supported in our study of elderly Korean women.
"A total of 1,737 elderly subjects aged over 60 years participated in a population-based study in Seoul, Korea (SWS Study 1999)," they said. "Amongst them, a total of 232 non-smoking and non-diabetic female subjects aged 60-89 years was randomly selected and compared with each other.
"Higher serum high-sensitivity CRP (hs-CRP) concentrations were shown in subjects with IGT than those with normal glucose tolerance (median 1.2 vs. 0.9, p
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Source: HighBeam Research, Pro-inflammatory cytokines not risk factors in older Korean women.