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Survivin, Bcl-2, p53 and bax expression increased in breast carcinoma.
2004 JUL 1 - (NewsRx.com & NewsRx.net) -- Survivin, Bcl-2, p53 and bax expression are increased in breast carcinoma.
According to published research from Turkey, "Survivin is a recently discovered member of the family of proteins that inhibits apoptosis. This anti-apoptotic compound can be detected in most types of cancer and expression is associated with a poor prognosis."
Using immunohistochemistry, "we investigated the expression of survivin in breast carcinomas and intraductal epithelial neoplasia of the breast to determine whether expression of this protein is associated with clinicopathological parameters such as grade, stage, mitotic rate.
"In 34 out of 43 cases (79.1%) of breast carcinoma and 22 out of 62 cases (35.4%) of intraductal epithelial neoplasia with mild, moderate and severe ductal epithelial," F. Kayeselcuk and colleagues reported, "cell hyperplasia stained positively for survivin. None of the histological parameters analyzed were significantly correlated with survivin expression in breast carcinomas."
Kayeselcuk continued, "In the carcinoma cases, survivin expression was positively correlated with expression of bcl-2, but was not correlated with expression of p53, bax, c-erbB-2 and estrogen, or progesterone. Some of the intraductal epithelial neoplasia cases with moderate or severe ductal epithelial hyperplasia ...
- Survivin, Bcl-2, p53 and bax expression increased in breast carcinoma.
- Newspaper article from: Cancer Weekly June 29, 2004 700+ words
...NewsRx.net) -- Survivin, Bcl-2, p53...are increased in breast carcinoma. According to...from Turkey, "Survivin is a recently...Expression of survivin, Bcl-2, p53 and bax in breast carcinoma and ductal intraepithelial...
- Staying alive: cell protein guards cancers.(survivin)
- Magazine article from: Science News Travis, John August 9, 1997 700+ words
...human gene encodes a protein, called survivin, that seems to delay or prevent cell...very few normal adult tissues, produce survivin, the protein offers an appealing target...effects, says Ambrosini. The discovery of survivin is "very exciting," agrees John C...
- Survivin enhances Aurora-B activity and localization in human cells.
- Newspaper article from: Cancer Weekly March 4, 2003 700+ words
...to a study from the United States, "survivin, one of the most tumor-specific gene...cytokinesis. However, the mechanism by which survivin regulates these two different processes is still elusive. Here, we show that survivin binds to the catalytic domain of Aurora...
- Survivin knockdown reduces the clonogenic survival of sarcoma cells without p53.
- Newspaper article from: Biotech Week April 14, 2004 700+ words
...NewsRx.com & NewsRx.net) -- Survivin knockdown reduces the clonogenic survival...According to a study from Germany, "survivin, a member of the inhibitors-of-apoptosis...is overexpressed in many tumor types. Survivin is a prognostic marker of soft-tissue...
- Survivin predicts cis-diamminedichloroplatinum sensitivity in gastric cancer.
- Newspaper article from: Cancer Weekly March 23, 2004 700+ words
...NewsRx.com & NewsRx.net) -- Survivin may be important in the development of...According to a study from Japan, "Survivin, a member of the inhibitor-of-apoptosis...apoptosis via caspase-3 activation, survivin may mediate the drug resistance...
- Taxol-mediated induction of survivin helps cancer escape self-destruction.
- Newspaper article from: Drug Week June 11, 2004 700+ words
...net) -- Taxol-mediated induction of survivin helps cancer escape self-destruction...to a study from the United States, "survivin is a novel anti-apoptotic protein that...arrest of cancer cells is associated with survivin induction, which preserves a survival...
- Survivin suppression halts the growth of aggressive non-Hodgkin's lymphoma.
- Newspaper article from: Blood Weekly April 15, 2004 700+ words
...NewsRx.com & NewsRx.net) -- Survivin suppression halts the growth of aggressive...published research from the United States, "survivin is a member of the inhibitor of apoptosis...inhibitor and a regulator of cell division. Survivin overexpression is common in many human...
- Antisense Drug Targeting Survivin Inhibits Growth Of Tumors In Animal Models;...
- Press release article from: Business Wire November 20, 2003 700+ words
...generation antisense drug that targets survivin, inhibited tumor growth in animal models...associated with significant reduction of survivin expression in tumors, evidence that...Targets and Cancer Therapeutics in Boston. Survivin is a molecule that promotes cell survival...
