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Researchers develop better understanding of tamoxifen resistance.
2004 JUL 1 - (NewsRx.com & NewsRx.net) -- A new study by researchers at Georgetown University's Lombardi Comprehensive Cancer Center may have implications for the thousands of breast cancer patients who develop resistance to antiestrogen drugs such as tamoxifen.
The work was published in the June 1, 2004, issue of Cancer Research.
The study, led by Robert Clarke, PhD, DSc, professor of oncology, shows that there may be an association between the gene IRF 1 (Interferon Regulatory Factor) and breast-tumor resistance to tamoxifen or other antiestrogen treatment. IRF 1 is a tumor-suppressor gene not previously associated with breast cancer.
"We hope that by pinpointing the connection between IRF 1 and breast cancer, we may be able to better identify which patients will respond to anti-estrogen treatment and which patients will ultimately develop anti-estrogen resistance," said Clarke.
Anti-estrogen therapy is currently the most effective means to manage hormone-dependent breast cancer and has the fewest serious side effects. Hormone-dependent breast cancer accounts for approximately one-third of all breast cancer cases. The most widely prescribed anti-estrogen therapy is tamoxifen, which blocks the activity of the estrogen hormone in breast tissue and can increase patients' overall survival. However about a third of breast tumors that might be expected to respond ...
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Source: HighBeam Research, Researchers develop better understanding of tamoxifen resistance.