AccessMyLibrary provides FREE access to over 30 million articles from top publications available through your library.
Create a link to this page
Copy and paste this link tag into your Web page or blog:
RARbeta P2 promoter methylation in RPFNA is biomarker for cancer risk.
2004 JUL 1 - (NewsRx.com & NewsRx.net) -- RARbeta P2 promoter methylation detected in breast cells collected via random periareolar fine needle aspiration (RPFNA) serves as a biomarker of breast cancer risk, study data show.
"Methylation of RARbeta P2 promoter is hypothesized to be an important early event in mammary carcinogenesis. RPFNA is a research technique developed to repeatedly sample mammary cells from the whole breast of asymptomatic high-risk subjects to assess both 1) breast cancer risk, and 2) response to chemoprevention [Fabian et al. J Natl Cancer Inst, 2000; Fabian et al. Clin Cancer Res, 2002]," said B.E. Ratliff and colleagues. "Coupling RARbeta P2 promoter methylation to RPFNA has the potential to enhance the sensitivity and specificity of RPFNA and to further delineate breast cancer risk."
At the 2004 annual meeting of the American Society of Clinical Oncology (ASCO), the researchers, hailing from Duke University, Ohio State University, and the University of Kansas Medical Center, described a study in which they tested "the frequency of RARbeta P2 methylation ... through methylation-specific-PCR (MS-PCR) in 1) tissue biopsy specimens from 17 low-risk, primary breast cancers with a 5-year patient clinical follow-up and 2) RPFNA samples performed in 21 subjects at increased risk of developing breast cancer.
"Risk was defined ...
- RARbeta P2 promoter methylation in RPFNA is biomarker for cancer risk.
- Newspaper article from: Health & Medicine Week June 28, 2004 700+ words
...presence of RARbeta P2 promoter methylation in RPFNA can contribute...assessment of breast cancer risk." The title of...was "RARbeta P2 promoter methylation: Potential biomarker...Aspiration in breast cancer risk assessment." This...
- Epstein-Barr virus in gastric adenocarcinomas: association with ethnicity and...
- Magazine article from: Journal of Clinical Pathology Vo, Q.N. Geradts, J. Gulley, M.L. Boudreau, D.A. Bravo, J.C. Schneider, B.G. September 1, 2002 700+ words
...reaction was used to detect CDKN2A promoter methylation in gastric adenocarcinomas from...without EBV, 32% exhibited CDKN2A promoter methylation and 26% had p16 protein loss...tumours containing EBV hod CDKN2A promoter methylation (p = 0.0003) and 90% showed...
- Promoter methylation of cyclin D2 gene may be involved in gastric carcinoma.
- Newspaper article from: Biotech Week January 14, 2004 700+ words
...gastric carcinoma." Oshimo and colleagues published their study in the International Journal of Oncology (Promoter methylation of cyclin D2 gene in gastric carcinoma. Int J Oncol, 2003;23(6):1663-1670). For additional information...
- OncoMethylome Sciences, of Liege, Belgium, signed a licensing and testing...
- Newspaper article from: BioWorld International June 18, 2008 700+ words
...Germany, in which OncoMethylome will provide MGMT gene promoter methylation testing services for Merck's clinical trial program...OncoMethylome to use the results of the OncoMethylome MGMT gene promoter methylation assay for optimizing glioblastoma multiforme treatment...
- The p300 gene promoter methylation is missing in acute leukemia.
- Newspaper article from: Cancer Weekly June 29, 2004 700+ words
...colleagues published the results of their research in Cancer Genetics and Cytogenetics (Absence of p300 gene promoter methylation in acute leukemia. Cancer Genet Cytogenet, 2004;150(2):164-167). For additional information, contact...
- Promoter methylation of E-cadherin gene in gastric mucosa associated with...
- Magazine article from: Gut Chan, A. O-O Lam, S-K. Wong, B. C-Y Wong, W-M Yuen, M-F Yeung, Y-H Hui, W-M Rashid, A. Kwong, Y-L April 1, 2003 700+ words
Background: E-cadherin is an adhesion molecule involved in tumour invasion/metastasis. Silencing of E-cadherin by promoter CpG methylation has been shown in both familial and sporadic gastric cancers. Helicobacter pylori is a class I carcinogen in gastric cancer. Aims: This study was undertaken to
- hTERT promoter methylation in human primary epithelial cells.(Biological...
- Magazine article from: Journal of the Alabama Academy of Science Andrews, Lucy G. Tollefsbol, Trygve O. Berletch, Joel Woodfin, William K. Pate, Mitchell S. April 1, 2003 700+ words
Telomerase is an enzyme known to be important in chromosomal stability and cellular senescence. By maintaining sequences of 5'-TTAGGG-3' on the ends of chromosomes telomerase keeps cells resistant to aging and unaffected by the restrictions imposed on them by the Hayflick limit. The enzyme's
- Effects of particulate matter on genomic DNA methylation content and iNOS...
- Magazine article from: Environmental Health Perspectives Tarantini, Letizia Bonzini, Matteo Apostoli, Pietro Pegoraro, Valeria Bollati, Valentina Marinelli, Barbara Cantone, Laura Rizzo, Giovanna Hou, Lifang Schwartz, Joel Bertazzi, Pier Alberto Baccarelli, Andrea February 1, 2009 700+ words
BACKGROUND: Altered patterns of gene expression mediate the effects of particulate matter (PM) on human health, but mechanisms through which PM modifies gene expression are largely undetermined. OBJECTIVES: We aimed at identifying short- and long-term effects of PM exposure on DNA methylation, a
- Genetic changes in saliva may flag smoking-related cancers.(Clinical...
- Magazine article from: Internal Medicine News Bates, Betsy August 1, 2008 700+ words
...correlations in the inhibition (promoter methylation) of tumor suppressor genes...specific inhibitors (total promoter methylation, inhibition of pl6, and...for us to completely control cancer risk; therefore, to avoid carcinogens...
- Changes in saliva may help detect smoking-related cancers.(Across Specialties)
- Magazine article from: Skin & Allergy News Bates, Betsy June 1, 2008 700+ words
...correlations in the inhibition (promoter methylation) of tumor suppressor genes...specific inhibitors (total promoter methylation, inhibition of p16, and...for us to completely control cancer risk; therefore, to avoid carcinogens...
Source: HighBeam Research, RARbeta P2 promoter methylation in RPFNA is biomarker for cancer risk.