Testing Laboratories. (cosmetics and toiletries)(includes list of abbreviations and geographical listing)(Who's Who) (Directory)

Argus Research, Inc. 7042 Fast Broadway Tucson, AZ 85710 USA Telephone 602-885-6793 F 602-886-8933

Senior personnel Frank E. Dunlap, MD, President James L. Boren, PhD, Technical Manager

Testing done Human, efficacy and safety,

Laboratory facilities 6,000 siq. ft. custom built facility. Spa. Full-time physician. Professional photographer. Non-invasive instrumentation. 8,000 registered subjects.

Laboratory specialties Efficacy and safety evaluation of drugs and cosmetics. SPF. Photoaging. D skin studies. Water resistance. Can fabricate water to any specifications for product testing.

Institute ASTER Hopital Cognacq-Jay 15, rue Eugene Millon 75015 Paris, France Telephone 1-45317389 F 1-45314832

Senior personnel Dr. Sabine Laquieze, Dermatologist Dr. Noel Goupil, Photobiologist Dr. Mare Pericoi, Ophthalmologist Dr. John J. Thebault, Director

Testing done Human, safe and efficacy

Laboratory facilities 60-bed clinic in central Paris. Dermatology and cosmetology departments were opened in 1986. ASTER-HAS its own analytical department (CEPHAC) and clinical department (APEX).

Laboratoru specialties Human patch testing, sensory testing, hydration or moisturizing properties and sebum rate, skin profiles with image analysis, biopsies and histologic studies, photobiology, ophthalmology, consumer testing.

Comments Founded in 1973, ASTER is the largest private contract research organization working on human health volunteers in France.

BIOCON, Inc. 416 Hungerford Drive, Suite 420 Rockville, MD 20850 USA Telephone 301-762-3202

Testing done Animal

Laboratory specialties BIOCON, Inc. is a research laboratory servicing the biomedical and biotechnology communities. We specialize in animal related services and are equipped to provide all phases of animal holding, animal breeding, custom antibody production, radio-isotope studies, animal diagnostics, contract management and contract technician services.

Comments Since our incorporation in 1978, BIOCON has specialized in animal related services. We are equipped to prov?de all phases of acute and sub-chronic toxicity testing. BIOCON'S goal is to provide a wide range of research animal related services to both private and government clients.

Bio/dynamics, Inc. Mettlers Road P.O. Box 2360 East Millstone, NJ 08875-2360 USA Telephone 908-873-2550 Telex 844597 Fax 908-873-3992 or 908-873-8899

Senior personnel G.K. Hogan, Phd, DABT, President A.L. Knezevich, DVM, Senior Vice President I.W. Daly, PhD, DABT, Senior N7ice President/

Director of Toxicology W.R. Richter, DVM, MS, DACVP, Vice President/

Director of Pathology M.R. Norman, Chief Operating Officer G.E. Dearlove, Phd, DABT, Manager,

North American Sales J.B. Townsend, Vice President/general Manager

Testing done Animal safe testing and analytical chemistry

Laboratory facilities 185,000 square feet of modem animal facilility, laboratory and office space located in central New Jersey between Princeton and New Brunswick.

Laboratory specialties Acute through lifetime toxicity-carcinogenicity, reproduction, neurotoxicity and inhalation (whole-body and head-only) studies its well as toxicokinetics.

Comments Founded in 1961. An international organization which provides contract toxicology, pharmacology, pathology, analytical chemistry-metabolism and regulatory services to the drug, chemical and cosmetics industries around the world.

Biologic Safety Research, Inc. 510 W. Hackley Avenue Muskegon, MI 49444 USA Telephone 616-739-5511

Senior personnel Robert F. Locke, MS, LATG Michael Kukulinski, BS, LATG Thomas J. Welsh, DVM, Phd Donald Waller, PIID, DABT

Testing done Acute, subacute, chronic toxicology

Laboratory facilities In-house 27,000 square feet laboratory and office.

Laboratory specialties Pharmaceutical/chemical testing. Sensitization testing, long term feeding/intravenous testing on all species. Hematology and clinical chemist . GLP, FDA, EPA studies.

Biosan Laboratories, Inc. 10657 Galaxie Ferndale, MI 48220-2133 USA Telephone 800-253-6800 Fax 313-544-3059 Telex 5106002431 BIOSAN

Senior personnel H. W. Rosstyioore, Phd, President L. A. Rossinoore, Vice President and General Manager

Testing done Physical and efficacy

Laboratory facilities Included in 6,000 sq. ft. of laboratories and support areas are anaerobic testing, laminar flow, diurnal incubation, fluorescent microscopy and HPLC analysis. Staff of eight microbiologists, technicians and support personnel.

Laboratory specialties Efficacy testing for preservatives in cosmetics. Troubleshooting and consultation for microbial contamination problems before, after or during production. HPLC analyses and other chemical methods to monitor preservative levels, including Kathon CG. Rapid turn-around stressed for all testing services.

Comments Founded in 1973 and remains one of the few private labs specializing in microbiological contamination control,

Bioscreen Testing Services, Inc. 3892 Del Amo Boulevard #707 Torrance, CA 90503 USA Telephone 213-214-0043 Fax 213-370-3642

Senior personnel Bradford L. Rope David A. Bruckner, PhD

Testing done Physical, human, efficacy and in vitro kit source

Laboratory facilities The facilities consist of a full-service chemistry and microbiology laboratory andalabtoperformclaimsubstantiationstudies.

Laboratory specialties The lab specializes in microbiology testing, claim substation, biogradability testing, and shelf life and quality assurance testing of finished product and raw materials. Also offered are small-scale consumer product assessment testing.

Comments The lab was founded in 1985 by Bradford Rope. It has grown to 5,000 sq. ft. of lab space for both microbiology and analytical chemistry. The facility serves the cosmetics, pharmaceutical and medical device industries. Bioscreen also manufactures the Microbox test kit.

Biosearch, Inc. P.O. Box 8598 Philadelphia, PA 19101 USA Telephone 215-739-4499 Fax 215-423-9210

Senior personnel Karl L. Gabriel, VMD,PHD, President James E. Long, ScD, Director, Quality Assurance Raymond Mark, MD, Medical Director, Director of Pathology Tracy Stoudemayer, Director, Clinical Studies Albert Kligman, MD, PhD, Consultant Dermatologist Frederich Urbach, MD, Consultant Dermatologist

Testing done Animal and human efficacy, claim substantiation; instrumental methods, regulatory affairs, product development

Laboratory facilities 24,000 sq. ft. of clinics, laboratories, animal rooms, offices, archives and support areas. Facilities are available for inhalation, photobiology and moisturization testing. Hot room, jacuzzi, indoor pool available. Fully computerized, In-house IRB, IACUC and Quality Assurance Unit.

Laboratory specialties Non-invasive instrumental methods; animal testing; acute, subchronic, inhalation toxicity; phototoxicity, photo-allergy; comodogenicity, USP test - plastics, histopathology evaluation. Human: irritation, allergy, phototoxicity, photo-allergy, comedogenicity, opthalmic safety. Standard, water-resistant, and water-proof claim substantiation or SPF-OTC monography; antiacne, hair care, antidandruff, antiperspirant-deodorant efficacy; moisturization, color cosmetics application/ wear, cell renewal, hair thickener, hair growth evaluations.

Bio-Technics Laboratories, Inc. 1153 Crenshaw Boulevard Los Angeles, CA 90019 USA Telephone 213-933-5991 Fax 213-939-7528

Senior personnel Dr. Richard J. Schlesinger, Phd, President Robert T. Lottritz, Vice President Quality Control Richard E. Sullivan, PhD, Vice President Operations

Testing done Animal and safety

Laboratory facilities Complete chemistry, microbiology and biology laboratories.

Laboratory specialties USP and AOAC tests (chemical, biological, toxicological and microbiological).

Comments Founded in 1952. Performs testing for toxicity, and quality control of pharmaceuticals, medical devices, cosmetics and other consumer products.

Bio whittaker, Inc. 8830 Biggs Ford Road Walkersville, MD 21793 USA Telephone 301-898-7025 Fax 301-845-8338 Telex 6919009

Senior personnel Noel Buterbaugh, President and COO Thomas Winkler, Vice President and General Manager,

Biotechnology Products Dr. Andrew O'Bierne, Vice President and General Manager,

Diagnostic Products Phillip Rohrer, Vice President and CFO

Testing done In vitro kit source

Laboratory facilities FDA-inspected facility for production of in vitro diagnostic products. Research and development facility for new products or custom work.

Laboratory specialties Specializes in in vitro testing cells and reagents. Largest supplier worldwide of diagnostic cell cultures. Custom production of cells and reagents.

Comments Founded in 1947 and specializes in in vitro toxicity test kits and diagnostic test kits, diagnostic cell cultures, cell culture media, serum, LAL test kits and molecular biology reagents.

Chemtest Laboratories 101 Midland Avenue Elmwood Park, NJ 07407 USA Telephone 201-797-2770 Fax 201-797-6960

Senior personnel Dr. Oscar Kim, Director

Testing done Ingredient, efficacy and safety testing

Laboratory facilities Independent lab, complete analytical testing equipment, pH, viscosity, flash point, spectroscopies, chromatographies.

Laboratory specialties Food, drug, cosmetic testing and analysis. Material safety data.

Comments Founded in February 1984.

Clinical Science Research international Alexandra House Hinchingbrooke Park Cambs PE18 8NT United Kingdom Telephone 0-480-432133 Fax 0-480-411646

Senior personnel Dr. Harry E. Amos, Managing Director Dr. Levin B. Logan, Commercial Director Dr. Avril MacLennan, Head, Consumer Products Testing

Testing done Human, safe, efficacy and home-use trials testing of consumer products

Laboratory facilities In-house photobiology unit, hot room, formulation laboratory. Trials conducted "on location" in Essex to ensure a larger pool of volunteers. External trials can be run nationally or internationally.

Laboratory specialties Antidandruff and other shampoo trials; patch testing; antiperspirant and deodorant efficacy; skin moisturizing potential; photoiriitationandpliotosensitizationstudies; sunscreen (SPF) efficacy, waterproofing, sweat and water-resistance; home-use trials on all consumer products.

Comments CSR has the largest volunteer panel in Europe for the testing of efficacy and/or safe of consumer products in man. CSR'S Clinical Investigation Unit also allows human volunteer studies under strict medical conditions. Tests can be carried out in-house or on location.

Clonetics Corporation 9620 Chesapeake Drive, Suite 201 San Diego, CA 92123-1324 USA Telephone 800-852-5663 Fax 619-541-0823 Telex 5101009924

Testing done Supply in vitro kits

Laboratory facilities Manufacturing and research laboratories in San Diego, California.

Laboratory specialties Clonetics manufactures and markets normal human cell culture systems, serum-free growth media and the Neutral Red Bioassay kit for cytotoxicicy assessment. Will perform neutral red uptake or neural red release under collaborative agreement. A three-day comprehensive NeutralRed Bioassay and cell culture techniques training class is also offered.

Comments Founded in 1984 to manufacture and market normal human cell culture systems to be used in research and toxicology laboratories.

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