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GABRA 3 gene may play role in unipolar major depressive disorder in females.
2004 JUN 3 - (NewsRx.com & NewsRx.net) -- A GABRA 3 gene polymorphism may play a pathophysiologic role in unipolar major depressive disorder in women, but not men, according to a study from Germany.
"There is evidence that genes coding for the gamma aminobutyric acid (GABA) receptor may be involved in the etiology of affective disorders," researchers at the University of Munich said, noting that a CA-repeat in the GABRA 3 gene recently had been associated with bipolar disorder.
V. Henkel and colleagues investigated whether this same polymorphism was associated with unipolar major depressive disorder. They published their study in the American Journal of Medical Genetics Part B - Neuropsychiatric Genetics (The gamma amino butyric acid (GABA) receptor alpha-3 subunit gene polymorphism in unipolar depressive disorder: A genetic association study. Am J Med Genet Part B, 2004;126B(1):82-87).
Study subjects were unrelated German men (73 patients, 70 controls) and women (128 patients, 81 controls) "of the same ethnogeographical origin," the researchers said.
GABRA 3 genotypic frequencies didn't differ between patients with unipolar major depressive ...
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