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Company launches colon cancer trial with GTI-2040.
2004 JUN 3 - (NewsRx.com & NewsRx.net) -- Lorus Therapeutics, Inc., announced the initiation of a clinical trial of GTI-2040 in a novel combination with oxaliplatin and capecitabine in patients with advanced unresectable colon cancer.
This new study is under the direction of Dr. Stephen Shibata at the City of Hope Comprehensive Cancer Center in Duarte, California, together with Dr. Heinz-Joseph Lenz at the University of Southern California in Los Angeles, California, Dr. David Gandara at the Davis Cancer Center, University of California in Sacramento, California, and Dr. Mark McNamara at the City of Hope Medical Group in Pasadena, California.
A key objective of this clinical study is to establish the optimal dose of this combination in colon cancer patients and the pharmacodynamic effects on cellular markers of antitumor activity when these agents are combined.
This trial is one of six clinical studies in a phase II clinical program for GTI-2040 in combination with other agents and in various tumor types sponsored by the Cancer Therapy Evaluation Program (CTEP), a U.S. National Cancer Institute program that sponsors clinical trials of novel compounds to accelerate their development.
"We are delighted with the support of the CTEP program to extend GTI-2040 development to colon cancer," said Dr. Jim Wright, CEO of Lorus Therapeutics, Inc. "Overlapping toxicities with common chemotherapy combinations can be a limiting factor in treating advanced diseases where single-agent therapy is rarely an option. GTI-2040 has good tolerability alone ...
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Source: HighBeam Research, Company launches colon cancer trial with GTI-2040.