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Enzyme inhibitor enhances the work of breast cancer adjuvant endocrine therapy.

Women's Health Weekly

| June 03, 2004 | COPYRIGHT 2004 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

2004 JUN 3 - (NewsRx.com & NewsRx.net) -- Enzyme inhibitor enhances the work of breast cancer adjuvant endocrine therapy.

According to a study from England, "the tissue inhibitors of metalloproteinases (TIMPs) control the activities of matrix metalloproteinases (MMPs) and as such, they have been recognized as potential suppressors of angiogenesis and tumor invasion and metastasis.

"However, TIMP-3 has several unique properties that set it apart from other TIMPs, including its ability to bind to extracellular matrix, inhibit related adamalysin metalloproteinases (ADAMs), and induce apoptosis," explained D.R. Edwards and colleagues, University of East Anglia, School of Biological Science.

"New data suggest that high levels of TIMP-3 mRNAs in human breast tumors are associated with success of adjuvant endocrine ...

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Source: HighBeam Research, Enzyme inhibitor enhances the work of breast cancer adjuvant...

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