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Study discusses the molecular biology of the estrogen receptors.
2004 JUN 3 - (NewsRx.com & NewsRx.net) -- Researchers review the newer anti-estrogens in treating breast cancer.
"Evidence for a role of ovarian factors in the growth of metastatic breast cancer was first recognized over 100 years ago. Today, anti-estrogens are central to the treatment of breast cancer of all stages," scientists in Germany report.
"We now understand that the action of estrogen is mediated by the estrogen receptors (ER), which are members of the nuclear receptor family of ligand-regulated transcription factors," wrote B. Hanstein and colleagues, University of Dusseldorf.
"In this article, we review the molecular mechanisms through which ER activates transcription of target genes and through which available anti-estrogens mediate their therapeutic effects," the researchers stated.
The researchers concluded: "We discuss possible mechanisms of failure of treatment with current anti-estrogens and how newer anti-estrogens under development attempt to ...
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Source: HighBeam Research, Study discusses the molecular biology of the estrogen receptors.