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Radiation improves survival in node-positive breast cancer patients.
2004 JUN 3 - (NewsRx.com & NewsRx.net) -- Postmastectomy radiotherapy improves overall survival in node-positive breast cancer patients.
"Postmastectomy irradiation substantially reduces the risk of locoregional recurrences (LRR) of breast carcinoma. However, debates continue on the prognostic factors for radiotherapy and the effect of radiotherapy on overall survival. The present study was undertaken to investigate the prognostic significance of level III positive nodes, along with the other factors for LRR, and to evaluate the effect of postmastectomy radiotherapy on overall survival among node-positive breast carcinoma treated systemically," scientists in Turkey report.
"Data from 549 consecutive node-positive breast cancer patients who underwent modified radical mastectomy and received adjuvant systemic therapy were studied retrospectively," said Bekir Kuru and colleagues at the Ankara Oncology Education and Research Hospital. "Prognostic factors for LRR and the effect of postmastectomy radiotherapy on overall survival were analyzed. Survival curves were generated by the Kaplan-Meier method, and multivariate analysis was performed by the Cox proportional hazard model. The 5-year locoregional recurrence rate is 7%. Apical invasion was found to be an independent prognostic factor for LRR ...
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Source: HighBeam Research, Radiation improves survival in node-positive breast cancer patients.