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Nuclear receptor LRH-1 regulates aromatase expression in adipose tissue.
2004 JUN 3 - (NewsRx.com & NewsRx.net) -- The nuclear receptor LRH-1 regulates aromatase expression in adipose tissue.
According to recent research from Australia, "Aromatase is the enzyme responsible for estrogen production, and is the product of the CYP19 gene. This gene is under the control of many tissue-specific promoters, each of which is regulated by different cohorts of factors. In normal breast adipose tissue, relatively low levels of aromatase are expressed via the action of the adipose specific promoter 1. 4.
"Breast tumor-derived factors such as prostaglandin E[subscript]2 (PGE[subscript]2) strongly stimulate aromatase expression via an alternative promoter, promoter II, leading to increased estrogenic drive and tumor growth," said Colin D. Clyne and colleagues at Prince Henry's Institute of Medical Research. "Understanding the mechanisms that regulate promoter II activity in tumorous breast may therefore identify new targets for breast cancer drug discovery. The current study describes the role of the orphan nuclear ...
- Nuclear receptor LRH-1 regulates aromatase expression in adipose tissue.
- Newspaper article from: Drug Week June 4, 2004 700+ words
...regulates aromatase expression in adipose tissue. According...modulating aromatase expression in breast adipose tissue." Clyne...Regulation of aromatase expression by the nuclear...LRH-1 in adipose tissue. Mol Cell...
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...the breast adipose tissue (e.g...increased aromatase expression and increased...displaying higher aromatase expression are more likely...further increase aromatase expression in the surrounding adipose tissue. These products...
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...osteoblastic cell line, helps elucidate aromatase expression regulation, researchers say. According...gene. The mechanisms regulating aromatase expression in bone, however, are unclear...Oncostatin M strongly stimulated aromatase expression in synergy with dexamethasone...
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...endocrine disruptor that increases aromatase expression in some human cancer cell lines...SF-1), in atrazine-induced aromatase expression. Materials and Methods Experiments...required for atrazine-induced aromatase expression, we examined SF-1 levels in atrazine...
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The function of brown adipose tissue is to transfer energy from food...thermoregulatory thermogenesis, brown adipose tissue is essential for classical nonshivering...the absence of functional brown adipose tissue), as well as for the cold acclimation...
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...with macrophage accumulation in adipose tissue. According to a study from the United States, "Obesity alters adipose tissue metabolic and endocrine function...characterize the changes that occur in adipose tissue with increasing adiposity, we...
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- Press release article from: Business Wire September 27, 2004 700+ words
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...affect prolactin receptor abundance and adipose tissue development in the neonatal lamb...nutrition and/or fetal number in adipose tissue." "Pregnant sheep were control fed...of PRLR were significantly higher in adipose tissue sampled from twins compared with singletons...
Source: HighBeam Research, Nuclear receptor LRH-1 regulates aromatase expression in adipose...