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Inverse relation found between leptin and BMD in hip-fractured women.
2004 JUN 3 - (NewsRx.com & NewsRx.net) -- An inverse association exists between leptin and bone mineral density (BMD) in hip-fractured women.
According to recent research published in the Journal of Endocrinological Investigation, "Fat body mass (FBM) is a strong predictor of both bone mineral density (BMD) and risk of hip fracture, but the mechanisms responsible are not completely understood. We addressed whether leptin is the link between FBM and BMD in hip-fractured women. Sixty-two of 74 women with hip fractures were evaluated.
"Serum leptin was measured by radioimmunoassay, 23.4[+ or -]9.1 days (mean[+ or -]SD) after fracture occurrence," said M. Di Monaco and colleagues at the Presidio Sanitario San Camillo in Turin. "BMD and body composition were assessed by dual-energy X-ray absorptiometry (DXA). As expected, a positive linear correlation was found between FBM and both leptin (r=0.782; p
"At linear multiple regression [dependent variable=femur BMD; independent variables=age, weight, height, body mass index, fracture type, term fracture-DXA, Barthel index score, FBM, lean body mass, serum PTH, serum 25(OH)vitamin D, and leptin], FBM was positively associated with BMD measured at all the five sites," reported the scientists. "The association between leptin and BMD was inverse and it was significant at four of the five sites of the BMD assessment.
"In conclusion, in a sample of hip-fractured women, ...
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