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2004 JUN 3 - (NewsRx.com & NewsRx.net) -- Women on hormone replacement therapy who find their memory just isn't what it used to be or that they're not as quick on the uptake should be sure they're getting enough calcium, researchers in Japan suggest.
They've found that in ovariectomized rats with inadequate calcium intake, progesterone interferes with the positive effect of estradiol on memory and learning.
T. Sato and colleagues at Kagoshima University studied how, under low-calcium conditions, ovarian steroids affect learning and memory in middle-aged female rats fed either a low-calcium (0.02% Ca) or a normal-calcium (1.25% Ca) diet. Then the rats' ovaries were removed (OVX) and they were divided into eight diet groups:
1) normal-calcium diet (OVX-normal-Ca group)
2) 17beta-estradiol treatment and a normal-calcium diet (E2 group)
3) progesterone treatment and a normal-calcium diet (P4 group)
4) 17beta-estradiol and progesterone treatments and a normal-calcium diet (E2 + P4 group)