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Method developed to monitor immune response against vaccinia virus.
2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Scientists have developed a high-throughput method to monitor the humoral immune response against vaccinia virus.
According to published research from Germany and Sweden, "Vaccination against smallpox is again considered in order to face a possible bioterrorist threat, but the nature and the level of the immune response needed to protect a person from smallpox after vaccination are not totally understood. Therefore, simple, rapid, and accurate assays to evaluate the immune response to vaccinia virus need to be developed. Neutralization assays are usually considered good predictors of vaccine efficacy and more informative with regard to protection than binding assays."
"Currently, the presence of neutralizing antibodies to vaccinia virus is measured using a plaque reduction neutralization test, but this method is time-consuming and labor-intensive and has a subjective readout," said Antonio Cosma at the GSF-National Research Center for Environment and Health and collaborators in Germany and Sweden. "Here, we describe an innovative neutralization assay based on a modified vaccinia virus Ankara (MVA) vector expressing the green fluorescent protein (WA-gfp). This MVA-gfp neutralization assay is rapid and sensitive and has a high-throughput potential.
"Thus, it is suitable to monitor the immune response and eventually the efficacy of a large campaign of vaccination ...
- Method developed to monitor immune response against vaccinia virus.
- News wire article from: Bioterrorism Week May 31, 2004 700+ words
...monitor the humoral immune response against vaccinia virus. According to...to evaluate the immune response to vaccinia virus need to be developed...monitor the humoral immune response against vaccinia virus. Clin Diagn Lab...
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...up: HIVAC-1e is vaccinia virus in Phase I The second...HIV genes into live vaccinia virus, causing the recombinant...ability to produce an immune response. The participants...vaccinia vaccine alone. Vaccinia virus was used for years...
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...inoculation of a laboratory worker with vaccinia virus. Although the patient had previously...virus recovered from the lesions. The vaccinia virus--specific immunoglobulin G levels...smallpox vaccine, formulated with vaccinia virus, is a highly effective immunizing...
Source: HighBeam Research, Method developed to monitor immune response against vaccinia virus.