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Fc-dependent antibodies protect mice against Rickettsia conorii.
2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Fc-dependent polyclonal antibodies and antibodies to outer membrane proteins A and B, but not to lipopolysaccharide, protect SCID mice against fatal Rickettsia conorii infection.
"An emphasis on cellular immunity against Rickettsia has led to neglect of analysis of the role of antibody. The availability of an excellent mouse model of spotted fever rickettsiosis enabled investigation of a potential role of antibody in immunity to Rickettsia conorii. C3H severe combined immunodeficiency (SCID) mice were passively transfused with monoclonal antibodies against rickettsial outer membrane protein A (OmpA), OmpB, or lipopolysaccharide (LPS), polyclonal anti-R. conorii serum, Fab fragments of polyclonal antiserum, or no antibodies and then challenged 48 hours later with 10 50% lethal doses (LD[subscript]50) of R. conorii," investigators in the United States report.
"All mice that received monoclonal antibodies against OmpA and two of four mice that received monoclonal antibodies against OmpB or polyclonal antisera were completely protected, but the recipients of anti-LPS antibodies or the Fab fragments were not protected," said Hui-Min Feng and colleagues at the University of Texas Medical Branch. "Polyclonal antibody treatment of C3H SCID mice that had been infected with 10 LD[subscript]50 of R. conorii 4 or 5 days earlier prolonged the life of the infected mice from 10.4 to 22.5 days and resulted in decreased levels of infectious rickettsiae in the spleen and liver 24 and 48 hours later.
"Treatment with protective antibodies resulted in the development of large aggregates of R. conorii antigens in splenic ...
- RickA protein of Rickettsia conorii activates Arp2/3 complex.
- Newspaper article from: Vaccine Weekly March 24, 2004 700+ words
...RickA protein of Rickettsia conorii activates the Arp2...that actin tails of Rickettsia conorii, another intracellular...RickA protein of Rickettsia conorii activates the Arp2...was prepared by Vaccine Weekly editors from staff...
- Pleurisy is found associated with Rickettsia conorii infection.
- Newspaper article from: Anti-Infectives Week July 21, 2003 700+ words
...Pleurisy can be caused by Rickettsia conorii infection, and is treatable with doxycycline. "Rickettsia conorii is endemic in Mediterranean...associated with antibodies to Rickettsia conorii. Clin Microbiol Infect, 2003...
- Fatal Rickettsia conorii subsp. israelensis infection, Israel.(DISPATCHES)(Case...
- Magazine article from: Emerging Infectious Diseases Weinberger, Miriam Keysary, Avi Sandbank, Judith Zaidenstein, Ronit Itzhaki, Avi Strenger, Carmela Leitner, Moshe Paddock, Christopher D. Eremeeva, Marina E. May 1, 2008 700+ words
...diagnosis of locally acquired Israeli spotted fever due to Rickettsia conorii subsp, israelensis in a traveler returning to Israel from India. ********** Rickettsia conorii subspecies israelensis, the cause of Israeli spotted fever...
- First documentation of Rickettsia conorii infection (strain Indian tick typhus)...
- Magazine article from: Emerging Infectious Diseases Parola, Philippe Fenollar, Florence Badiaga, Sekene Brouqui, Philippe Raoult, Didier September 1, 2001 700+ words
...first serologically documented case of infection caused by Rickettsia conorii (strain ITT) in a French traveler returning from India...assumed to be the agent causing ITT. It was designated as Rickettsia conorii, the agent of Mediterranean spotted fever, which occurs...
- Febrile illness associated with Rickettsia conorii infection in dogs from...
- Magazine article from: Emerging Infectious Diseases Solano-Gallego, Laia Kidd, Linda Trotta, Michele Di Marco, Marco Caldin, Marco Furlanello, Tommaso Breitschwerdt, Edward December 1, 2006 700+ words
...and molecular evidence of acute, febrile illness associated with Rickettsia conorii in 3 male Yorkshire terriers from Sicily (Italy). ********** Rickettsia conorii, transmitted by Ripicephalus sanguineus, causes Mediterranean...
- Family outbreak of Rickettsia conorii infection.(Brief Article)
- Magazine article from: Emerging Infectious Diseases Shazberg, G. Moise, J. Terespolsky, N. Hurvitz, H. September 1, 1999 700+ words
...IgM) immunofluorescence assay (IFA) 7 to 8 days after admission of each child confirmed the diagnosis of Rickettsia conorii infection. Spotted fever is the generic name given to a variety of tickborne rickettsial diseases distributed...
- Israeli spotted fever Rickettsia (Rickettsia conorii Complex) associated with...
- Magazine article from: Emerging Infectious Diseases Bacellar, Fatima Beati, Lorenza Franca, Ana Pocas, Jose Regnery, Russel Filipe, Armindo November 1, 1999 700+ words
...is endemic in Portugal, where it is a reportable disease with approximately 1,000 new cases per year (1). Rickettsia conorii has been thought to be the only pathogenic rickettsia of the spotted fever group in Portugal (2), as well as...
- New rickettsia risk factors study results reported from R. Sousa et...
- Newspaper article from: Biotech Week September 3, 2008 700+ words
...for and pathophysiology of fatal Rickettsia conorii infection in Portuguese patients...fatal outcome for 140 patients with Rickettsia conorii infection admitted to 13 Portuguese...infected with the Malish strain of Rickettsia conorii, and 69 (49%) were infected with...
