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Two pneumococcal vaccines safe and effective in American Indian infants.

Vaccine Weekly

| June 02, 2004 | COPYRIGHT 2004 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Results from a pilot study indicated that two octavalent pneumococcal conjugate vaccines are safe and effective in American Indian infants.

"We evaluated the safety and immunogenicity of two octavalent pneumococcal polysaccharide vaccines (serotypes 3, 4, 6B, 9V, 14, 18C, 19F, and 23F) conjugated to either diphtheria toxoid (PncD) or tetanus protein (PncT) among White Mountain Apache and Gila River Indian Community infants. This was a prospective, non-randomized, open label, comparative pilot study of PncD and PncT. Since this was a pilot study, a small sample size of 60 infants was enrolled," researchers in the United States report.

"Enrolled healthy infants received either PncD or PncT at 2, 4, and 6 months of age," said Angelia Eick and colleagues at Johns Hopkins University. "Antibody concentrations were measured by enzyme-immunoassay (EIA) prior to each dose and 1 month after the last dose. Local reaction rates were similar between PncD and PncT groups. The geometric mean concentrations (GMCs) were significantly higher for PncD than PncT for serotype 3 whereas GMCs were ...

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