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Onchocerca secreted larval acidic proteins are protective.
2004 JUN 2 - (NewsRx.com & NewsRx.net) -- The secreted larval acidic proteins (SLAPs) of Onchocerca species are encoded by orthologues of the alt gene family of Brugia malayi and have host protective potential.
"Onchocerca volvilus is a tissue-dwelling, vector-borne nematode parasite of humans and the causative agent of onchocerciasis, or 'River Blindness'. Resistance to infection is associated with immune responses to the infective, third-stage (1-3) larvae. The antigens of greatest interest for their vaccine potential are surface and secreted molecules," scientists in England report.
"We have previously identified a family of secreted larval acidic proteins (SLAPs) from the L3 larvae of O. volvulus by biosynthetic labeling," said Yang Wu and collaborators at the Liverpool School of Tropical Medicine, University of Liverpool, and Imperial College School of Medicine. "Here, we provide further characterization of these molecules following cloning and expression of the corresponding cDNAs. Using protein sequencing, we show that SLAPs are members of the alt gene family first described in the lymphatic filarial parasite, Brugia malayi.
"Ov-ALT-1 and Ov-ALT-2 correspond with 20- and 18-kDa SLAPs," reported the researchers. "Both proteins are highly acidic and related by sequence, differing chiefly in an 8-amino acid deletion from Ov-ALT-2. By immunochemistry, we confirm that 0v-ALTs are highly stage-specific, being expressed exclusively in late L2 and L3 larvae during growth in the vector. They are synthesized and stored in the glandular esophagus. Secretion is triggered by the resumption of development in the definitive host and occurs via the ...
- Onchocerca secreted larval acidic proteins are protective.
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Source: HighBeam Research, Onchocerca secreted larval acidic proteins are protective.