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Norovirus virus-like particles induce specific immune responses.
2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Recombinant virus-like particles of a norovirus (Genogroup II strain) administered intranasally and orally with mucosal adjuvants LT and LT(R192G) in BALB/c mice induce specific humoral and cellular Th1/Th2-like immune responses.
"We investigated the immune response induced by mucosal immunization of BALB/c mice with virus-like particles (VLPs) of a genogroup II norovirus, Dijon 171/96 virus, produced in the baculovirus system. VLPs administered alone by the intranasal route induced a high serum antibody response as well as fecal IgA, which were enhanced when the heat-labile Escherichia coli toxin or its non-toxic mutant LT(R192G) was co-administered. In these conditions, the oral route was also efficient," scientists in France report.
"Cytokine production by cells from different lymphoid tissues was then assessed after in vitro restimulation," said Beatrice Nicollier-Jamot and colleagues at the University of Bourgogne. "A Th1/Th2-like response was observed in cervical lymph node and Peyer's patch (PP) cell cultures from mice intranasally or orally immunized with either adjuvant indicating that, on the assumption that T cells are the primary ...
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Source: HighBeam Research, Norovirus virus-like particles induce specific immune responses.