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Cyclic peptides that bind to meningococcal LPS antibody characterized.
2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Scientists have characterized cyclic peptides that bind to a monoclonal antibody against meningococcal L3,7,9 lipopolysaccharides.
According to a study from Norway, "There is still no general vaccine for prevention of disease caused by group-B meningococcal strains. Meningococcal lipopolysaccharides (LPSs) have received attention as potential vaccine candidates, but concerns regarding their safety have been raised. Peptide mimics of LPS epitopes may represent safe alternatives to immunization with LPS. The monoclonal antibody (MoAb) 9-2-L3,7,9 specific for Neisseria meningitidis LPS immunotype L3,7,9 is bactericidal and does not cross-react with human tissue.
"To explore the possibility of isolating peptide mimics of the epitope recognized by MoAb 9-2-L3,7,9, we have constructed two phage display libraries of six and nine random amino acids flanked by cysteines," said Vigdis Lauvrak and colleagues at the University of Oslo. "Furthermore, we developed a system for the easy exchange of peptide-encoding sequences from the phage-display system to a hepatitis B core (HBc) expression system. Cyclic peptides that specifically bound MoAb 9-2-L3,7,9 at a site overlapping with the LPS-binding site were selected from both libraries.
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Source: HighBeam Research, Cyclic peptides that bind to meningococcal LPS antibody characterized.