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Response to conserved epitope linked to protection from malaria.
2004 JUN 2 - (NewsRx.com & NewsRx.net) -- A CD4+ T-cell immune response to a conserved epitope in the circumsporozoite protein correlates with protection from natural Plasmodium falciparum infection and disease.
According to a study from an international team of researchers, "Many human T-cell responses specific for epitopes in Plasmodium falciparum have been described, but none has yet been shown to be predictive of protection against natural malaria infection. Here we report a peptide-specific T-cell assay that is strongly associated with protection of humans in The Gambia, West Africa, from both malaria infection and disease.
"The assay detects interferon-gamma-secreting CD4+ T cells specific for a conserved sequence from the circumsporozoite protein, which binds to many human leukocyte antigen (HLA)-DR types," said William H. H. Reece at the University of Oxford and collaborators in England, Belgium, Gambia, and the United States. "The correlation was observed using a cultured, rather than an ex vivo, ELISPOT assay that measures central memory-type T cells rather than activated effector T cells. These findings ...
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Source: HighBeam Research, Response to conserved epitope linked to protection from malaria.