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Malaria vaccine results indicate protection related to antibody levels.
2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Immunization of Saimiri sciureus monkeys with Plasmodium falciparum merozoite surface protein-3 and glutamate-rich protein suggests that protection is related to antibody levels.
"The immunogenicity and protective efficacy of various antigen-adjuvant formulations derived either from the merozoite-surface protein-3 (MSP-3) or the glutamate-rich protein (GLURP) of Plasmodium falciparum were evaluated in Saimiri sciureus monkeys. These proteins were selected for immunogenicity studies based primarily on their capacity of inducing an antibody-dependent cellular inhibition effect on parasite growth," scientists in Brazil report.
"Some of the S. sciureus monkeys immunized with MSP-3[subscript]212-380-AS02 or GLURP[subscript]27-500-alum were able to fully or partially control parasitemia upon an experimental P. falciparum [Falciparum Uganda Palo Alto (FUP-SP) strain] blood-stage infection, and this protection was related to the prechallenge antibody titers induced," said Leonardo J. M. Carvalho at the Instituto Oswaldo Cruz in Rio De Janeiro and collaborators in Brazil, Denmark, and France. "The data are indicative that MSP-3 and GLURP can induce protective immunity against an ...
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Source: HighBeam Research, Malaria vaccine results indicate protection related to antibody...