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Displacement in 6725 SERA peptide analogue protects against malaria.
2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Induction and displacement of an alpha helix in the 6725 SERA peptide analogue confers protection against Plasmodium falciparum malaria.
"The protein called serine repeat antigen (SERA) is a P. falciparum malaria antigen; high activity erythrocyte binding peptides have been identified in this protein. One of these, the 6725 peptide (non-immunogenic and non-protective), was analyzed for immunogenicity and protective activity in Aotus monkeys, together with several of its analogues," investigators in Colombia report.
"These peptides were studied by (HNMR)-H-1 to try to correlate their structure with their biological function," stated Martha Patricia Alba and colleagues at the Fundacion Instituto de Inmunologia de Colombia. "These peptides showed helical regions having differences in their position, except for randomly structured 6725. It is shown that replacing some amino acids induced immunogenicity and protectivity against experimental malaria and changed their ...
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Source: HighBeam Research, Displacement in 6725 SERA peptide analogue protects against malaria.