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Plasmodium gametocyte stages neglected in vaccine development.
2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Plasmodium vivax and Plasmodium falciparum gametocyte stages are neglected in malaria vaccine development.
"Plasmodium gametocytes are responsible for transmission from the vertebrate host to the mosquito. Plasmodium gametocytes undergo a complex cycle from asexual stages, through a poorly understood process characterized by expression of stage-specific proteins and adhesion molecules. Gametocytes are capable of inducing specific humoral IgG, and cellular responses, which include induction of TNF-alpha, IFN-gamma, and gammadelta+ lymphocyte proliferation, in addition to immune responses to other stages of the parasite (sporozoite, exo-erythrocytic stages, erythrocytic stages)," scientists in Mexico report.
"Although transmission-blocking vaccines against Plasmodium do not currently include components against the gametocytes (rather they focus on gametes, zygotes, or ookinetes, stages which occur in the mosquito), further understanding of the mechanisms underlying gametocytogenesis and immune responses against these stages may provide additional strategies for more effective transmission ...
- Plasmodium gametocyte stages neglected in vaccine development.
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