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Plasmodium falciparum peptides bind to human hepatocytes.
2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Sporozoite and liver stage antigen Plasmodium falciparum peptides bind specifically to human hepatocytes.
According to recent research from Colombia, "Sporozoite and Liver Stage Antigen (SALSA) sequence synthetic peptides were used in HepG2 cell binding assays to identify regions involved in parasite invasion. SALSA 20608 ([superscript]21IWASEKKDEKEASEQGEESHY[superscript]40) and 20611 ([superscript]64KKDDGTDKVQEKVLEKSPKY[superscript]83) peptides were determined as having high binding activity in HepG2 cell assays, some of them were located in immunogenic regions. Immunofluorescence antibody test with 24276 (20608 peptide analogue, CGIWSSMKMDEKMAAMQGEESHCG) showed sporozoite and merozoite reactivity.
"These data suggest SALSA high activity binding peptides' (HABPs) possible role in hepatic cell invasion and merozoite invasion of erythrocytes," wrote Alvaro Puentes and colleagues ...
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