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DNA vaccine induces protection against intracellular bacterial pathogen.
2004 JUN 2 - (NewsRx.com & NewsRx.net) -- DNA vaccination with gp96-peptide fusion proteins induces protection against an intracellular bacterial pathogen.
"Effective vaccination using in vitro peptide-loaded heat-shock proteins (HSP), tumor-derived HSP, and HSP fusion proteins has been shown in viral, parasite, and tumor model systems. We demonstrate protective DNA vaccination using gp96-peptide fusion proteins against the intracellular bacterial pathogen Listeria monocytogenes in a mouse model. In contrast to previous studies using pathogen-derived HSP as vaccine vehicles, we used recombinant endogenous (Mus musculus) gp96 (GRP94) as a carrier for immunodominant listerial peptides," scientists in Germany report.
"Analyses of the cellular immune response revealed profound epitope-specific IFN-gamma and cytotoxic T cell responses," said Ulrike K. Rapp and Stefan H. Kaufmann at the Max Planck Institute for Infection Biology. "Our findings suggest a predominantly MHC I-restricted T cell response to DNA vaccination with gp96 fusion proteins ...
- DNA vaccine induces protection against intracellular bacterial pathogen.
- Newspaper article from: Proteomics Weekly May 31, 2004 700+ words
...peptide fusion proteins induces protection...against an intracellular bacterial pathogen...peptide fusion proteins against the intracellular bacterial pathogen...peptide fusion proteins induces protection...against an intracellular bacterial ...
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- Newspaper article from: Gene Therapy Weekly February 5, 2004 700+ words
...Acute myeloid leukemia fusion proteins deregulate maintenance and...rearrangements that produce fusion proteins with aberrant transcriptional...activities. Expression of AML fusion proteins in transgenic mice increases...
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- Press release article from: PR Newswire April 18, 2007 700+ words
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- Newspaper article from: Proteomics Weekly June 1, 2009 700+ words
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- Press release article from: M2 Presswire April 19, 2007 700+ words
...Showing Peregrine's Immunocytokine Fusion Proteins Reduce Growth of B-Cell Lymphoma...Cancer Research (AACR) showed that fusion proteins combining the anti-cancer cytokines...studies, the antibody-cytokine fusion proteins generated a robust anti-tumor response...
- New fusion proteins study findings have been reported by researchers at...
- Newspaper article from: Proteomics Weekly August 11, 2008 700+ words
...Heidelberg, Australia report (see also Fusion Proteins). "Recombinant rat and human procholecystokinin...expressed as glutathione S-transferase fusion proteins in E. coli. The fusion proteins were bound to glutathione-agarose...
- Research on fusion proteins detailed by D.M. Wang and co-authors.(Report)
- Newspaper article from: Proteomics Weekly April 27, 2009 700+ words
...The Trx (thioredoxin)/sTRAIL fusion proteins were expressed in the form of inclusion...and renaturation, the refolded fusion proteins with a purity of > 98% were...M. Wang and colleagues (see also Fusion Proteins). The researchers concluded...
- Reports outline fusion proteins research from O. Ramadan and colleagues.
- Newspaper article from: Proteomics Weekly April 20, 2009 700+ words
...Biological Chemistry report (see also Fusion Proteins). "Here we sought to identify the...Ca2+ channel by generating GST fusion proteins of the intracellular loops, N terminus...kinase assay was performed for the GST fusion proteins, and their phosphorylation was assessed...
Source: HighBeam Research, DNA vaccine induces protection against intracellular bacterial...