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Vaccinia virus encoding T-cell chemoattractant is attenuated in vivo.
2004 JUN 2 - (NewsRx.com & NewsRx.net) -- A recombinant vaccinia virus encoding the interferon-inducible T-cell alpha chemoattractant is attenuated in vivo.
According to recent research from Australia, "Murine interferon-inducible T-cell alpha chemoattractant (I-TAC) is a potent non-ELR CXC chemokine that predominantly attracts activated T lymphocytes, binds to the receptor CXCR3 and is induced by interferon-gamma (IFN-gamma). We analyzed I-TAC expression by reverse transcriptase-polymerase chain reaction during three different virus-infection models in mice, respiratory syncytial virus (RSV), influenza A, and vaccinia virus western reserve (VV-WR).
"In the lungs from mice infected with RSV or influenza A viruses, peak expression of I-TAC coincided with peak viremia," reported N. H. R. Hamilton and colleagues at Australian National University. "Surprisingly, there was no expression in the lungs of mice infected with vaccinia, unlike the elevated expression shown previously for other interferon-regulated chemokines, such as Crg2 and Mig. To further investigate the importance of this difference during vaccinia infection in mice, a recombinant virus encoding I-TAC (rVV I-TAC) was generated.
"Studies in C57BL/6 and Swiss nude mice showed that I-TAC expression caused increased mononuclear cell infiltration and significantly attenuated the VV," stated the ...
- Vaccinia virus encoding T-cell chemoattractant is attenuated in vivo.
- Newspaper article from: Biotech Week June 2, 2004 700+ words
...net) -- A recombinant vaccinia virus encoding the interferon-inducible...RSV), influenza A, and vaccinia virus western reserve (VV-WR...Immunology (A recombinant vaccinia virus encoding the interferon-inducible...
- Accidental infection of laboratory worker with vaccinia virus. (Dispatches).
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- Newspaper article from: Proteomics Weekly January 26, 2004 700+ words
...com & NewsRx.net) -- The vaccinia virus encodes a previously uncharacterized...that function at the mitochondria. Vaccinia virus, the prototypic member of the Poxviridae...previously unidentified protein in vaccinia virus, is responsible for the inhibition...
- Method developed to monitor immune response against vaccinia virus.
- News wire article from: Bioterrorism Week May 31, 2004 700+ words
...the humoral immune response against vaccinia virus. According to published research from...to evaluate the immune response to vaccinia virus need to be developed. Neutralization...presence of neutralizing antibodies to vaccinia virus is measured using a plaque reduction...
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- Newspaper article from: Vaccine Weekly October 14, 2009 700+ words
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- Newspaper article from: Vaccine Weekly August 26, 2009 700+ words
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- Secondary and tertiary transfer of vaccinia virus among U.S. military...
- Newspaper article from: Morbidity and Mortality Weekly Report Barkdoll, TW Cabiad, RB Tankersley, MS Adkins, JL Jilly, B Herriford, G Whelen, AC Bell, CA Fairchok, MP Raynor, LC Garde, VA Rothmeyer, VM Mahlen, SD Engler, RJ Collins, LC Duran, LL Huynh, MT Bradshaw, RD Grabenstein JD February 13, 2004 700+ words
...vaccination program (1). Because vaccinia virus is present on the skin at the site...describes cases of contact transfer of vaccinia virus among vaccinated military personnel...findings indicate that contact transfer of vaccinia virus is rare. Continued efforts are needed...
