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P6 protein intranasal vaccine protects against Haemophilus influenzae.
2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Intranasal vaccination with recombinant P6 protein and adamantylamide dipeptide as mucosal adjuvant confers efficient protection against otitis media and lung infection by nontypeable Haemophilus influenzae.
According to published research from Argentina and Germany, "Nontypeable Haemophilus influenzae (NTHi) is a leading etiologic agent of otitis media in children and recurrent respiratory infections in patients with chronic obstructive pulmonary disease. The highly conserved outer membrane protein P6 constitutes a promising vaccine candidate antigen. However, the small amount of P6 produced by this fastidious microorganism renders large-scale production difficult. Controversial data also exist concerning the suitability of recombinant P6 (rP6) as a vaccine antigen.
"Therefore, we performed a comparative evaluation of the immunogenicity and efficacy of native P6 and rP6 in mice intranasally vaccinated with adamantylamide dipeptide (AdDP) as an adjuvant," said Gustavo M. Bertot and collaborators at Ricardo Gutierrez Children Hospital in Argentina and the German Research Center for Biotechnology in Germany. "High titers of P6-specific serum antibodies were elicited in mice vaccinated with either native P6 or rP6, which cross-recognized both antigens. However, rP6 stimulated stronger mucosal responses. Mice vaccinated with rP6 ...
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Source: HighBeam Research, P6 protein intranasal vaccine protects against Haemophilus influenzae.