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Artificial antigen presentation reviewed.
2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Scientists review artificial antigen presentation in a recent issue of Nature Biotechnology.
"Artificial antigen presentation aims to accelerate the establishment of therapeutic cellular immunity. Artificial antigen-presenting cells (AAPCs) and their cell-free substitutes are designed to stimulate the expansion and acquisition of optimal therapeutic features of T cells before therapeutic infusion, without the need for autologous antigen-presenting cells," scientists in the United States report.
"Compelling recent advances include fibroblast AAPCs that process antigens, magnetic beads that are antigen specific, novel T-cell costimulatory combinations, the augmentation of therapeutic potency of adoptively transferred T lymphocytes by interleukin-15, and the safe use of dendritic cell-derived exosomes pulsed with tumor antigen," stated Jiyun V. Kim and colleagues at the Memorial Sloan-Kettering Cancer Center. "Whereas the safety and potency of the various systems warrant further preclinical and clinical studies, these emerging ...
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Source: HighBeam Research, Artificial antigen presentation reviewed.