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C-terminal antibody binding domain of C. albicans mp58 is protective.
2004 JUN 2 - (NewsRx.com & NewsRx.net) -- The C-terminal antibody binding domain of Candida albicans mp58 represents a protective epitope during candidiasis.
"The 58-kDa surface mannoprotein of Candida albicans (mp58) elicits strong antibody responses during infection. Epitope mapping with sera from patients with candidiasis and control individuals indicated the presence of multiple IgG-reactive continuous epitopes on the protein, expanding both the amino- and carboxy-terminal domains and several internal regions. These immunoreactive regions were similar to the ones previously identified using sera from immunized animals," scientists in the United States and Spain report.
"Two of the epitopic regions (including the C-terminal domain) showed increased reactivity with antibodies present in sera from patients with candidiasis as compared to control individuals," said Angel Viudes at the University of Texas and collaborators in the United States and Spain. "Patients who survived the infection displayed increased antibody reactivity towards the C-terminal epitope as compared to those succumbing to candidiasis. A monoclonal antibody directed towards this epitopic region conferred protection in serum therapy experiments in ...
- C-terminal antibody binding domain of C. albicans mp58 is protective.
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