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Plasmids costimulate DNA vaccine against carcinoembryonic antigen.
2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Plasmids encoding membrane-bound IL-4 or IL-12 strongly costimulate DNA vaccination against carcinoembryonic antigen (CEA).
"Vaccination with plasmids encoding an antigen of interest (DNA vaccination) is a new strategy to achieve effective immunization against many agents. DNA vaccination can be ameliorated by co-administration of plasmids encoding a cytokine. Thus far, only plasmids encoding soluble cytokines have been used for this purpose," scientists in Canada and the United States report.
"However, these plasmids can induce release of cytokines into the circulation and could potentially cause many undesirable effects," said Rabindranath Chakrabarti and collaborators at the University of Toronto in Canada and Harvard University and Pittsburgh University in the U.S. "We undertook this study to determine whether membrane-bound cytokines, which would restrict their localization at the site of administration, can act as immunoadjuvants. We and others have previously shown that plasmids encoding soluble IL-4 and IL-12 are effective adjuvants for DNA vaccination.
"In this study, we demonstrate that DNA co-vaccination with membrane-bound IL-4 (mbIL-4) or membrane-bound IL-12 (mbIL-12) both enhance anti-CEA immunity, as detected by in vitro and in vivo assays," reported the ...
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Source: HighBeam Research, Plasmids costimulate DNA vaccine against carcinoembryonic antigen.