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Heat shock protein 70-pulsed dendritic cells elicit tumor immunity.
2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Tumor-derived heat shock protein 70-pulsed dendritic cells elicit tumor-specific cytotoxic T lymphocytes (CTLs) and tumor immunity.
"Vaccination with autologous tumor-derived heat shock proteins (Hsp), such as Hsp70, Hsp90, and gp96, has been demonstrated to elicit specific immune responses against the tumor from which the Hsps were isolated. The effect of Hsp immunization is wholly dependent on the presence of functional antigen-presenting cells (APCs) in the immunized host, and Hsp receptors on APCs have recently been identified. Here we show that bone marrow-derived dendritic cells (DCs) are able to internalize HSP-peptide complex and that peptides are re-presented by DCs via the major histocompatibility complex (MHC) class I presentation pathway," investigators in Japan report.
"In addition, immunization with tumor-derived HSP-pulsed DCs induces strong cytotoxic T cell (CTL) responses against multiple antigenic peptides in a transporter-associated antigen processing (TAP)-dependent manner," stated Gosel Ueda and collaborators at Sapporo Medical University and the University of the Ryukyus. "The results of the ...
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Source: HighBeam Research, Heat shock protein 70-pulsed dendritic cells elicit tumor immunity.