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Complement function in antibody-mediated cancer immunotherapy described.
2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Researchers describe complement function in monoclonal-antibody-mediated cancer immunotherapy in a recent issue of Trends in Immunology.
"Complement activation by monoclonal antibodies can cause direct tumor cell lysis or enhance antibody-dependent cell-mediated cytotoxicity. However, tumor cells are protected from complement-mediated injury by membrane-bound complement regulatory proteins [mCRP) that are often expressed at elevated levels on tumor cells. Recent studies indicate that blocking or overwhelming the function of tumor cell mCRP might substantially improve the efficacy of monoclonal antibody (mAb) immunotherapy," scientists in the Netherlands and United States report.
"In addition, the use of beta-glucan as an adjuvant for mAb immunotherapy enables iC3b deposited on tumor cells by mAbs to activate complement receptor 3 (CR3) on effector cells, thus inducing CR3-dependent cellular cytotoxicity," stated Kyra A. Gelderman and collaborators at Leiden University in the Netherlands and the ...
- CASEBOOK: Appeal decisions - Commercial and industrial - Veterinary surgery...
- Magazine article from: Planning (UK) April 12, 2002 700+ words
The Wheel House Veterinary Group has secured permission for the change of use of a shop in the Chalfont St Giles local centre in Buckinghamshire to a veterinary surgery, with an inspector concluding that the new use had the potential to generate considerable pedestrian and vehicular activity. The
- Poxvirus used for delivery of stimulatory molecules to melanoma tumors.
- Newspaper article from: Vaccine Weekly February 18, 2004 700+ words
...Delivery, Skin Cancer, Dermatology, Immunotherapy, Vaccine Development, and Oncology. This article was prepared by Vaccine Weekly editors from staff and other reports. Copyright 2004, Vaccine Weekly via NewsRx.com & NewsRx.net.
- Broadly cross-reactive HIV-neutralizing antibody Fab identified.
- Newspaper article from: Vaccine Weekly February 18, 2004 700+ words
...Therapy, Vaccine Development, Monoclonal Antibodies, Diagnostics, and Immunotherapy. This article was prepared by Vaccine Weekly editors from staff and other reports. Copyright 2004, Vaccine Weekly via NewsRx.com & NewsRx.net.
- Arginine-glysine-aspartate motif enhances immunogenicity of antigens.
- Newspaper article from: Vaccine Weekly February 18, 2004 700+ words
...Delivery, Vaccine Development, Vaccine Efficacy, Immunology, and Immunotherapy. This article was prepared by Vaccine Weekly editors from staff and other reports. Copyright 2004, Vaccine Weekly via NewsRx.com & NewsRx.net.
- Cancer vaccine using low affinity epitopes proves successful in mice.
- Newspaper article from: Vaccine Weekly February 18, 2004 700+ words
...This article may be viewed at https://www.the-jci.org/press/19418.pdf. This article was prepared by Vaccine Weekly editors from staff and other reports. Copyright 2004, Vaccine Weekly via NewsRx.com & NewsRx.net.
- DNA induces T helper type 1-mediated responses in antigen-primed mice.
- Newspaper article from: Vaccine Weekly February 18, 2004 700+ words
...Bacteriology, Biological Therapy, Immunology, Immunotherapy, Oncology, and Proteomics. This article was prepared by Vaccine Weekly editors from staff and other reports. Copyright 2004, Vaccine Weekly via NewsRx.com & NewsRx.net.
- Researcher reviews novel cancer vaccines.
- Newspaper article from: Vaccine Weekly February 18, 2004 700+ words
...Vaccine Development, Vaccine Efficacy, Immunotherapy, Proteomics, and Oncology. This article was prepared by Vaccine Weekly editors from staff and other reports. Copyright 2004, Vaccine Weekly via NewsRx.com & NewsRx.net.
- Call for increase in flu vaccination among young children.
- Newspaper article from: Vaccine Weekly February 18, 2004 700+ words
...administration should make it possible to increase the use of influenza vaccination." This article was prepared by Vaccine Weekly editors from staff and other reports. Copyright 2004, Vaccine Weekly via NewsRx.com & NewsRx.net.
- Positive results of cholera vaccine trial in Bangladesh reported.
- Newspaper article from: Vaccine Weekly February 18, 2004 700+ words
...vaccines against anthrax or other organisms that might be used as biowarfare agents. This article was prepared by Vaccine Weekly editors from staff and other reports. Copyright 2004, Vaccine Weekly via NewsRx.com & NewsRx.net.
- Typhoid/hepatitis A vaccine effective as booster dose in primed adults.
- Newspaper article from: Vaccine Weekly February 18, 2004 700+ words
...Vaccine Efficacy, Vaccine Development, Hepatitis A Virus, Virology, and Hepatology. This article was prepared by Vaccine Weekly editors from staff and other reports. Copyright 2004, Vaccine Weekly via NewsRx.com & NewsRx.net.
Source: HighBeam Research, Complement function in antibody-mediated cancer immunotherapy...