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Flea-borne transmission model evaluates vaccines against bubonic plague.
2004 JUN 2 - (NewsRx.com & NewsRx.net) -- A flea-borne transmission model is useful for evaluating vaccine efficacy against naturally acquired bubonic plague.
"A flea-to-mouse transmission model was developed for use in testing new candidate vaccines for the ability to protect against flea-borne plague. The model was used to evaluate a recombinant fusion protein vaccine consisting of the Yersinia pestis F1 and V antigens. After one to three challenges with Y. pestis-infected fleas, 14 of 15 unvaccinated control mice developed plague, with an average septicemia level of 9.2x10[superscript]8 Y. pestis CFU/mL," investigators in the United States report.
"None of 15 vaccinated mice developed the disease after similar challenges, and serological testing indicated that transmitted bacteria were eliminated by the immune system before extensive replication and systemic infection could occur," said Clayton O. Jarrett and colleagues at the National Institute of Allergy and Infectious Diseases. "The transmission and development of disease in control mice correlated with the number of bites by blocked fleas but not with the total number of fleabites."
The researchers concluded, "The model ...
- Flea-borne transmission model evaluates vaccines against bubonic plague.
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Source: HighBeam Research, Flea-borne transmission model evaluates vaccines against bubonic...