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Hedgehog-interacting protein prevents basal cell carcinoma.
2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Recombinant hedgehog-interacting protein provides immunoprevention of basal cell carcinomas.
"Basal cell carcinomas (BCCs) are driven by abnormal hedgehog signaling and highly overexpress several hedgehog target genes. We report here our use of one of these target genes, hedgehog-interacting protein (Hip1), as a tumor-associated antigen for immunoprevention of BCCs in Ptchl[superscript]+/- mice treated with ionizing radiation. Hip 1 rnRNA is expressed in adult mouse tissues at levels considerably lower than those in BCCs," scientists writing in the Journal of Experimental Medicine report.
"Immunization with either of two large recombinant Hip1 polypeptides was well tolerated in Ptchl[superscript]+/- mice, induced B and T cell responses detectable by enzyme-linked immunosorbent assay, Western blot, delayed type hypersensitivity, and enzyme-linked immunospot assay, and reduced the number of BCCs by 42% (p
"We conclude that immunization with proteins specifically up-regulated by hedgehog signaling may hold promise as a preventive option for patients such as those with the basal cell nevus syndrome who are destined to develop large numbers of basal cell ...
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SAN FRANCISCO -- If 5-year outcomes from treatment of basal cell carcinoma with imiquimod are like the 3-year...surgery for BCC, he added. BY SHERRY BOSCHERT San Francisco Bureau
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- Hedgehog-interacting protein prevents basal cell carcinoma.
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...of California-San Francisco, National Cancer...those with the basal cell nevus syndrome...Immunoprevention of basal cell carcinomas with...of California-San Francisco, San Francisco...100-Room 269, San Francisco, CA 94110, USA...subject areas ...
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...long before 6 years of wound and compression therapy. 3. Basal cell carcinoma is the correct answer. Looking closely at Figure...Barbara Bielan, BSN, RN, NPC, is a Nurse Practitioner, San Francisco, CA; and a Dermatology Nursing Editorial Board Member.
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- Magazine article from: British Medical Journal Wong, CSM Strange, RC Lear, JT October 4, 2003 700+ words
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Abstract Basal cell carcinoma is the most common of the...chronic local invasion. Metastatic basal cell carcinoma is a rare clinical entity...Approximately 85% of all metastatic basal cell carcinomas arise in the head and neck...
Source: HighBeam Research, Hedgehog-interacting protein prevents basal cell carcinoma.