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Neutralizing antibodies against HIV-1 tat antigen characterized.
2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Scientists have characterized neutralizing human monoclonal antibodies against human immunodeficiency virus type 1 tat antigen.
According to a study from France, "The human immunodeficiency virus Tat regulatory protein is essential for virus replication and pathogenesis. From human peripheral blood mononuclear cells of three Tat toxoid-immunized volunteers, we isolated five Tat-specific human monoclonal antibodies (HMAbs): two full-length immunoglobulin G (IgG) antibodies and three single-chain fragment-variable (scFv) antibodies. The two IgGs were mapped to distinct epitopes within the basic region of Tat, and the three scFvs were mapped to the N-terminal domain of Tat.
"The three scFvs were highly reactive with recombinant Tat in Western blotting or immunoprecipitation, but results were in contrast to those for the two IgGs, which are sensitive to a particular folding of the protein," said Emmanuel Moreau at Hopital St-Louis in Paris and collaborators in France. "In transactivation assays, scFvs were able to inhibit both active recombinant Tat and native Tat secreted by a ...
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Source: HighBeam Research, Neutralizing antibodies against HIV-1 tat antigen characterized.