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Components of HIV vaccine are recognized by T-helper cells.
2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Minor components of a multi-envelope HIV vaccine are recognized by type-specific T-helper cells.
"HIV has thus far evaded control by vaccines, in part due to the high diversity among viral isolates. To effectively target HIV diversity, we propose that multi-envelope HIV vaccines should be designed. We hypothesize that minor components of complex envelope cocktail vaccines can be immunogenic and can thus elicit unique T-cell responses," researchers in the United States report.
"To test our hypothesis, we first defined unique T-helper cell determinants on 1007 (clade B) and UG92005 (UG, clade D) gp140 envelope proteins delivered by DNA vaccination," stated Xiaoyan Zhan and colleagues at the University of Tennessee. "Peptide-specific T-helper cell responses were then used as markers for type-specific immune activity. Results showed that type-specific responses could indeed be generated when an envelope protein was represented as only 1 part per 100 of the total vaccine. We also found that type-specific T-helper cell responses were elicited and sustained toward an envelope that appeared only once within a ...
- Components of HIV vaccine are recognized by T-helper cells.
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