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Prevalence of dermatologic reactions to smallpox vaccine reported.

Vaccine Weekly

| June 02, 2004 | COPYRIGHT 2004 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Researchers report the prevalence of benign dermatologic reactions to smallpox vaccination in adults in a recent issue of Clinical Infectious Diseases.

"A phase 1 smallpox vaccine trial involving 350 adult volunteers was conducted. Of these subjects, 250 were naive to vaccinia virus vaccine (i.e., 'vaccinia naive'). Volunteers received a new cell-cultured smallpox vaccine or a live vaccinia virus vaccine," scientists in the United States report.

"Nine self-limiting rashes (3.6%) were observed in the vaccinia-naive group," said Richard N. Greenberg and collaborators at the University of Kentucky and DynPort Vaccine Company. "None of the vaccinia-experienced patients had a rash. Rashes appeared 6-19 days after vaccination and had five different clinical presentations. Five volunteers had urticarial rashes that resolved within 4-15 days, one had an exanthem that lasted 20 days, and one each presented with folliculitis, contact dermatitis, and erythematous papules found only on the hands and fingers.

"Volunteers reported pruritus, tingling, ...

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Source: HighBeam Research, Prevalence of dermatologic reactions to smallpox vaccine reported.

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